Symbol: Name: ID: |
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) GFS:2482 |
Gene name: | VPS26A |
Chromosome: | 10q21.1 |
Previous Symbols: | VPS26 |
Previous Names: | vacuolar protein sorting 26 (yeast homolog), "vacuolar protein sorting 26 (yeast)", "vacuolar protein sorting 26 homolog A (yeast)" |
Aliases: | Hbeta58, PEP8A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353654 | Rat Genome Database ID: | RGD:1359254 |
HGNC ID: | HGNC:12711 | RefSeq IDs: | NM_001035260 |
Entrez Gene ID: | 9559 | Ensembl Gene ID: | ENSG00000122958 |
VEGA IDs: | OTTHUMG00000018376 | UniProt ID: | O75436 |
UCSC ID: | uc001jpb.2 | OMIM ID: | 605506 |
Pubmed: | PMID1638986 PMID 9653160 | ||
CCDS IDs: | CCDSCCDS7286.1 CCDS CCDS41536.1 |
Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).
Products for VPS26A gene
Catalog | Product Name | Application | Company |
GFS:E02482 | vacuolar protein sorting 26 homolog A (S. pombe); ELISA kit | ELISA | n/a |
GFS:A02482 | vacuolar protein sorting 26 homolog A (S. pombe); Anti | ANTIBODIES | n/a |
GFS:P02482 | vacuolar protein sorting 26 homolog A (S. pombe); Protien | Protien | n/a |