Symbol: Name: ID: |
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) GFS:3690 |
Gene name: | VPS29 |
Chromosome: | 12q24 |
Previous Symbols: | |
Previous Names: | vacuolar protein sorting 29 (yeast homolog), "vacuolar protein sorting 29 (yeast)" |
Aliases: | PEP11, DC7, DC15 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1928344 | Rat Genome Database ID: | RGD:1308332 |
HGNC ID: | HGNC:14340 | RefSeq IDs: | NM_016226 |
Entrez Gene ID: | 51699 | Ensembl Gene ID: | ENSG00000111237 |
VEGA IDs: | UniProt ID: | Q9UBQ0 | |
UCSC ID: | uc001tqx.2 | OMIM ID: | 606932 |
Pubmed: | PMID11062004 | ||
CCDS IDs: | CCDSCCDS41832.1 |
VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.
This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).
Products for VPS29 gene
Catalog | Product Name | Application | Company |
GFS:E03690 | vacuolar protein sorting 29 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A03690 | vacuolar protein sorting 29 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P03690 | vacuolar protein sorting 29 homolog (S. cerevisiae); Protien | Protien | n/a |