Symbol: Name: ID: |
TRPM8 transient receptor potential cation channel, subfamily M, member 8 GFS:6859 |
Gene name: | TRPM8 |
Chromosome: | 2q37 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2181435 | Rat Genome Database ID: | RGD:620762 |
HGNC ID: | HGNC:17961 | RefSeq IDs: | NM_024080 |
Entrez Gene ID: | 79054 | Ensembl Gene ID: | ENSG00000144481 |
VEGA IDs: | OTTHUMG00000059129 | UniProt ID: | Q7Z2W7 |
UCSC ID: | uc002vvh.2 | OMIM ID: | 606678 |
Pubmed: | PMID16382100 | ||
CCDS IDs: | CCDSCCDS33407.1 |
Transient receptor potential cation channel subfamily M member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene.
Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Products for TRPM8 gene
Catalog | Product Name | Application | Company |
GFS:E06859 | transient receptor potential cation channel, subfamily M, member 8; ELISA kit | ELISA | n/a |
GFS:A06859 | transient receptor potential cation channel, subfamily M, member 8; Anti | ANTIBODIES | n/a |
GFS:P06859 | transient receptor potential cation channel, subfamily M, member 8; Protien | Protien | n/a |