Symbol: Name: ID: |
TRPM4 transient receptor potential cation channel, subfamily M, member 4 GFS:6887 |
Gene name: | TRPM4 |
Chromosome: | 19q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ20041 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915917 | Rat Genome Database ID: | RGD:620244 |
HGNC ID: | HGNC:17993 | RefSeq IDs: | NM_001195227 |
Entrez Gene ID: | 54795 | Ensembl Gene ID: | ENSG00000130529 |
VEGA IDs: | UniProt ID: | Q8TD43 | |
UCSC ID: | uc002pmw.2 | OMIM ID: | 606936 |
Pubmed: | PMID11535825 PMID 16382100 | ||
CCDS IDs: | CCDSCCDS33073.1 |
Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010].
Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Products for TRPM4 gene
Catalog | Product Name | Application | Company |
GFS:E06887 | transient receptor potential cation channel, subfamily M, member 4; ELISA kit | ELISA | n/a |
GFS:A06887 | transient receptor potential cation channel, subfamily M, member 4; Anti | ANTIBODIES | n/a |
GFS:P06887 | transient receptor potential cation channel, subfamily M, member 4; Protien | Protien | n/a |