Symbol: Name: ID: |
TRPM7 transient receptor potential cation channel, subfamily M, member 7 GFS:6888 |
Gene name: | TRPM7 |
Chromosome: | 15q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CHAK1, LTRPC7, TRP-PLIK |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929996 | Rat Genome Database ID: | RGD:620053 |
HGNC ID: | HGNC:17994 | RefSeq IDs: | NM_017672 |
Entrez Gene ID: | 54822 | Ensembl Gene ID: | ENSG00000092439 |
VEGA IDs: | UniProt ID: | Q96QT4 | |
UCSC ID: | uc001zyt.3 | OMIM ID: | 605692 |
Pubmed: | PMID11161216 PMID 11385574 PMID 16382100 | ||
CCDS IDs: | CCDSCCDS42035.1 |
Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.[provided by RefSeq, May 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Products for TRPM7 gene
Catalog | Product Name | Application | Company |
GFS:E06888 | transient receptor potential cation channel, subfamily M, member 7; ELISA kit | ELISA | n/a |
GFS:A06888 | transient receptor potential cation channel, subfamily M, member 7; Anti | ANTIBODIES | n/a |
GFS:P06888 | transient receptor potential cation channel, subfamily M, member 7; Protien | Protien | n/a |