Symbol: Name: ID: |
TRPM6 transient receptor potential cation channel, subfamily M, member 6 GFS:6889 |
Gene name: | TRPM6 |
Chromosome: | 9q21.13 |
Previous Symbols: | HOMG, HSH |
Previous Names: | hypomagnesemia, secondary hypocalcemia |
Aliases: | CHAK2, FLJ22628 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2675603 | Rat Genome Database ID: | RGD:1309942 |
HGNC ID: | HGNC:17995 | RefSeq IDs: | NM_001177310 |
Entrez Gene ID: | 140803 | Ensembl Gene ID: | ENSG00000119121 |
VEGA IDs: | OTTHUMG00000020027 | UniProt ID: | Q9BX84 |
UCSC ID: | uc004ajl.1 | OMIM ID: | 607009 |
Pubmed: | PMID10021370 PMID 12032570 PMID 16382100 | ||
CCDS IDs: | CCDSCCDS6647.1 |
TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010].
Function: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
Products for TRPM6 gene
Catalog | Product Name | Application | Company |
GFS:E06889 | transient receptor potential cation channel, subfamily M, member 6; ELISA kit | ELISA | n/a |
GFS:A06889 | transient receptor potential cation channel, subfamily M, member 6; Anti | ANTIBODIES | n/a |
GFS:P06889 | transient receptor potential cation channel, subfamily M, member 6; Protien | Protien | n/a |