Symbol: Name: ID: |
TRPM2 transient receptor potential cation channel, subfamily M, member 2 GFS:2151 |
Gene name: | TRPM2 |
Chromosome: | 21q22.3 |
Previous Symbols: | TRPC7 |
Previous Names: | |
Aliases: | KNP3, LTRPC2, NUDT9L1, NUDT9H, EREG1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1351901 | Rat Genome Database ID: | RGD:1311889 |
HGNC ID: | HGNC:12339 | RefSeq IDs: | NM_003307 |
Entrez Gene ID: | 7226 | Ensembl Gene ID: | ENSG00000142185 |
VEGA IDs: | OTTHUMG00000040840 | UniProt ID: | O94759 |
UCSC ID: | uc002zew.1 | OMIM ID: | 603749 |
Pubmed: | PMID9806837 PMID 11385575 PMID 16382100 | ||
CCDS IDs: | CCDSCCDS13710.1 |
Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene. The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq].
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Products for TRPM2 gene
Catalog | Product Name | Application | Company |
GFS:E02151 | transient receptor potential cation channel, subfamily M, member 2; ELISA kit | ELISA | n/a |
GFS:A02151 | transient receptor potential cation channel, subfamily M, member 2; Anti | ANTIBODIES | n/a |
GFS:P02151 | transient receptor potential cation channel, subfamily M, member 2; Protien | Protien | n/a |