Symbol: Name: ID: |
TGFB1 transforming growth factor, beta 1 GFS:1584 |
Gene name: | TGFB1 |
Chromosome: | 19q13.1 |
Previous Symbols: | TGFB, DPD1 |
Previous Names: | |
Aliases: | CED, TGFbeta |
Name Aliases: | Camurati-Engelmann disease |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98725 | Rat Genome Database ID: | RGD:69051 |
HGNC ID: | HGNC:11766 | RefSeq IDs: | NM_000660 |
Entrez Gene ID: | 7040 | Ensembl Gene ID: | ENSG00000105329 |
VEGA IDs: | UniProt ID: | P01137 | |
UCSC ID: | uc002oqh.1 | OMIM ID: | 190180 |
Pubmed: | PMID10631145 PMID 10843814 | ||
CCDS IDs: | CCDSCCDS33031.1 |
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene. This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
Products for TGFB1 gene
Catalog | Product Name | Application | Company |
GFS:E01584 | transforming growth factor, beta 1; ELISA kit | ELISA | n/a |
GFS:A01584 | transforming growth factor, beta 1; Anti | ANTIBODIES | n/a |
GFS:P01584 | transforming growth factor, beta 1; Protien | Protien | n/a |