| Symbol: Name: ID: |
TGFBR3 transforming growth factor, beta receptor III GFS:1592 |
| Gene name: | TGFBR3 |
| Chromosome: | 1p33-p32 |
| Previous Symbols: | |
| Previous Names: | transforming growth factor, beta receptor III (betaglycan, 300kDa) |
| Aliases: | betaglycan, BGCAN |
| Name Aliases: | betaglycan proteoglycan |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:104637 | Rat Genome Database ID: | RGD:61821 |
| HGNC ID: | HGNC:11774 | RefSeq IDs: | NM_001195683 |
| Entrez Gene ID: | 7049 | Ensembl Gene ID: | ENSG00000069702 |
| VEGA IDs: | OTTHUMG00000010097 | UniProt ID: | Q03167 |
| UCSC ID: | uc001doh.2 | OMIM ID: | 600742 |
| Pubmed: | PMID1333192 PMID 1319842 | ||
| CCDS IDs: | CCDSCCDS30770.1 | ||
Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Function: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
Products for TGFBR3 gene
| Catalog | Product Name | Application | Company |
| GFS:E01592 | transforming growth factor, beta receptor III; ELISA kit | ELISA | n/a |
| GFS:A01592 | transforming growth factor, beta receptor III; Anti | ANTIBODIES | n/a |
| GFS:P01592 | transforming growth factor, beta receptor III; Protien | Protien | n/a |
