Symbol: Name: ID: |
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) GFS:1591 |
Gene name: | TGFBR2 |
Chromosome: | 3p22 |
Previous Symbols: | MFS2 |
Previous Names: | transforming growth factor, beta receptor II (70-80kD) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98729 | Rat Genome Database ID: | RGD:69651 |
HGNC ID: | HGNC:11773 | RefSeq IDs: | NM_001024847 |
Entrez Gene ID: | 7048 | Ensembl Gene ID: | ENSG00000163513 |
VEGA IDs: | OTTHUMG00000130569 | UniProt ID: | P37173 |
UCSC ID: | uc003cen.2 | OMIM ID: | 190182 |
Pubmed: | PMID1319842 PMID 15235604 | ||
CCDS IDs: | CCDSCCDS2648.1 CCDS CCDS33727.1 |
Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene. It is a tumor suppressor gene. This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq].
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
Products for TGFBR2 gene
Catalog | Product Name | Application | Company |
GFS:E01591 | transforming growth factor, beta receptor II (70/80kDa); ELISA kit | ELISA | n/a |
GFS:A01591 | transforming growth factor, beta receptor II (70/80kDa); Anti | ANTIBODIES | n/a |
GFS:P01591 | transforming growth factor, beta receptor II (70/80kDa); Protien | Protien | n/a |