Symbol: Name: ID: |
TGFBR1 transforming growth factor, beta receptor 1 GFS:1590 |
Gene name: | TGFBR1 |
Chromosome: | 9q22 |
Previous Symbols: | |
Previous Names: | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) |
Aliases: | ALK-5, ACVRLK4 |
Name Aliases: | activin A receptor type II-like kinase, 53kDa |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98728 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11772 | RefSeq IDs: | NM_001130916 |
Entrez Gene ID: | 7046 | Ensembl Gene ID: | ENSG00000106799 |
VEGA IDs: | OTTHUMG00000020353 | UniProt ID: | P36897 |
UCSC ID: | uc004azc.2 | OMIM ID: | 190181 |
Pubmed: | PMID1319842 PMID 8530052 | ||
CCDS IDs: | CCDSCCDS6738.1 CCDS CCDS47998.1 |
The protein encoded by TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
Products for TGFBR1 gene
Catalog | Product Name | Application | Company |
GFS:E01590 | transforming growth factor, beta receptor 1; ELISA kit | ELISA | n/a |
GFS:A01590 | transforming growth factor, beta receptor 1; Anti | ANTIBODIES | n/a |
GFS:P01590 | transforming growth factor, beta receptor 1; Protien | Protien | n/a |