Symbol: Name: ID: |
TOP3B topoisomerase (DNA) III beta GFS:1794 |
Gene name: | TOP3B |
Chromosome: | 22q11.22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333803 | Rat Genome Database ID: | RGD:1309468 |
HGNC ID: | HGNC:11993 | RefSeq IDs: | NM_003935 |
Entrez Gene ID: | 8940 | Ensembl Gene ID: | ENSG00000100038 |
VEGA IDs: | OTTHUMG00000150833 | UniProt ID: | O95985 |
UCSC ID: | uc002zvs.2 | OMIM ID: | 603582 |
Pubmed: | PMID9786842 PMID 9074928 | ||
CCDS IDs: | CCDSCCDS13797.1 |
DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described. [provided by RefSeq].
Function: Possesses negatively supercoiled DNA relaxing activity.
Products for TOP3B gene
Catalog | Product Name | Application | Company |
GFS:E01794 | topoisomerase (DNA) III beta; ELISA kit | ELISA | n/a |
GFS:A01794 | topoisomerase (DNA) III beta; Anti | ANTIBODIES | n/a |
GFS:P01794 | topoisomerase (DNA) III beta; Protien | Protien | n/a |