Symbol: Name: ID: |
TOPBP1 topoisomerase (DNA) II binding protein 1 GFS:6099 |
Gene name: | TOPBP1 |
Chromosome: | 3q22.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0259, TOP2BP1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1920018 | Rat Genome Database ID: | RGD:1562949 |
HGNC ID: | HGNC:17008 | RefSeq IDs: | NM_007027 |
Entrez Gene ID: | 11073 | Ensembl Gene ID: | ENSG00000163781 |
VEGA IDs: | UniProt ID: | Q92547 | |
UCSC ID: | uc003eps.2 | OMIM ID: | 607760 |
Pubmed: | PMID9461304 PMID 9039502 | ||
CCDS IDs: | CCDSCCDS46919.1 |
DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.
Products for TOPBP1 gene
Catalog | Product Name | Application | Company |
GFS:E06099 | topoisomerase (DNA) II binding protein 1; ELISA kit | ELISA | n/a |
GFS:A06099 | topoisomerase (DNA) II binding protein 1; Anti | ANTIBODIES | n/a |
GFS:P06099 | topoisomerase (DNA) II binding protein 1; Protien | Protien | n/a |