Symbol: Name: ID: |
TOP2B topoisomerase (DNA) II beta 180kDa GFS:1792 |
Gene name: | TOP2B |
Chromosome: | 3p24 |
Previous Symbols: | |
Previous Names: | topoisomerase (DNA) II beta (180kD) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98791 | Rat Genome Database ID: | RGD:1586156 |
HGNC ID: | HGNC:11990 | RefSeq IDs: | NM_001068 |
Entrez Gene ID: | 7155 | Ensembl Gene ID: | ENSG00000077097 |
VEGA IDs: | OTTHUMG00000155596 | UniProt ID: | Q02880 |
UCSC ID: | uc003cdj.2 | OMIM ID: | 126431 |
Pubmed: | PMID1309226 PMID 1333583 | ||
CCDS IDs: | CCDSCCDS46776.1 |
DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for TOP2B gene
Catalog | Product Name | Application | Company |
GFS:E01792 | topoisomerase (DNA) II beta 180kDa; ELISA kit | ELISA | n/a |
GFS:A01792 | topoisomerase (DNA) II beta 180kDa; Anti | ANTIBODIES | n/a |
GFS:P01792 | topoisomerase (DNA) II beta 180kDa; Protien | Protien | n/a |