Symbol: Name: ID: |
TOP3A topoisomerase (DNA) III alpha GFS:1793 |
Gene name: | TOP3A |
Chromosome: | 17p12-p11.2 |
Previous Symbols: | TOP3 |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1197527 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11992 | RefSeq IDs: | NM_004618 |
Entrez Gene ID: | 7156 | Ensembl Gene ID: | ENSG00000177302 |
VEGA IDs: | OTTHUMG00000059391 | UniProt ID: | Q13472 |
UCSC ID: | uc002gsx.1 | OMIM ID: | 601243 |
Pubmed: | PMID9450867 | ||
CCDS IDs: | CCDSCCDS11194.1 |
DNA topoisomerase 3-alpha is an enzyme that in humans is encoded by the TOP3A gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.
Products for TOP3A gene
Catalog | Product Name | Application | Company |
GFS:E01793 | topoisomerase (DNA) III alpha; ELISA kit | ELISA | n/a |
GFS:A01793 | topoisomerase (DNA) III alpha; Anti | ANTIBODIES | n/a |
GFS:P01793 | topoisomerase (DNA) III alpha; Protien | Protien | n/a |