Symbol: Name: ID: |
TLR4 toll-like receptor 4 GFS:1665 |
Gene name: | TLR4 |
Chromosome: | 9q33.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | hToll, CD284 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:96824 | Rat Genome Database ID: | RGD:3870 |
HGNC ID: | HGNC:11850 | RefSeq IDs: | NM_138554 |
Entrez Gene ID: | 7099 | Ensembl Gene ID: | ENSG00000136869 |
VEGA IDs: | OTTHUMG00000021046 | UniProt ID: | O00206 |
UCSC ID: | uc004bjz.2 | OMIM ID: | 603030 |
Pubmed: | PMID9435236 PMID 9237759 | ||
CCDS IDs: | CCDSCCDS6818.1 |
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq].
Products for TLR4 gene
Catalog | Product Name | Application | Company |
GFS:E01665 | toll-like receptor 4; ELISA kit | ELISA | n/a |
GFS:A01665 | toll-like receptor 4; Anti | ANTIBODIES | n/a |
GFS:P01665 | toll-like receptor 4; Protien | Protien | n/a |