Symbol: Name: ID: |
TLR3 toll-like receptor 3 GFS:1663 |
Gene name: | TLR3 |
Chromosome: | 4q35 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CD283 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2156367 | Rat Genome Database ID: | RGD:735171 |
HGNC ID: | HGNC:11849 | RefSeq IDs: | NM_003265 |
Entrez Gene ID: | 7098 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | O15455 | |
UCSC ID: | uc003iyq.2 | OMIM ID: | 603029 |
Pubmed: | PMID9435236 | ||
CCDS IDs: | CCDSCCDS3846.1 |
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Products for TLR3 gene
Catalog | Product Name | Application | Company |
GFS:E01663 | toll-like receptor 3; ELISA kit | ELISA | n/a |
GFS:A01663 | toll-like receptor 3; Anti | ANTIBODIES | n/a |
GFS:P01663 | toll-like receptor 3; Protien | Protien | n/a |