Symbol: Name: ID: |
TLR1 toll-like receptor 1 GFS:1661 |
Gene name: | TLR1 |
Chromosome: | 4p14 |
Previous Symbols: | |
Previous Names: | |
Aliases: | rsc786, KIAA0012, CD281 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1341295 | Rat Genome Database ID: | RGD:1309975 |
HGNC ID: | HGNC:11847 | RefSeq IDs: | NM_003263 |
Entrez Gene ID: | 7096 | Ensembl Gene ID: | ENSG00000174125 |
VEGA IDs: | UniProt ID: | Q15399 | |
UCSC ID: | uc003gtl.2 | OMIM ID: | 601194 |
Pubmed: | PMID9435236 PMID 7584026 | ||
CCDS IDs: | CCDSCCDS33973.1 |
TLR 1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system.[1][2] TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281 (cluster of differentiation 281). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Products for TLR1 gene
Catalog | Product Name | Application | Company |
GFS:E01661 | toll-like receptor 1; ELISA kit | ELISA | n/a |
GFS:A01661 | toll-like receptor 1; Anti | ANTIBODIES | n/a |
GFS:P01661 | toll-like receptor 1; Protien | Protien | n/a |