Symbol: Name: ID: |
TLR10 toll-like receptor 10 GFS:4825 |
Gene name: | TLR10 |
Chromosome: | 4p14 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CD290 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | RGD:1311569 | |
HGNC ID: | HGNC:15634 | RefSeq IDs: | NM_001017388 |
Entrez Gene ID: | 81793 | Ensembl Gene ID: | ENSG00000174123 |
VEGA IDs: | OTTHUMG00000128578 | UniProt ID: | Q9BXR5 |
UCSC ID: | uc003gtk.2 | OMIM ID: | 606270 |
Pubmed: | PMID11267672 | ||
CCDS IDs: | CCDSCCDS3445.1 |
Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010].
Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Products for TLR10 gene
Catalog | Product Name | Application | Company |
GFS:E04825 | toll-like receptor 10; ELISA kit | ELISA | n/a |
GFS:A04825 | toll-like receptor 10; Anti | ANTIBODIES | n/a |
GFS:P04825 | toll-like receptor 10; Protien | Protien | n/a |