Symbol: Name: ID: |
TK2 thymidine kinase 2, mitochondrial GFS:1646 |
Gene name: | TK2 |
Chromosome: | 16q22-q23.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913266 | Rat Genome Database ID: | RGD:1309279 |
HGNC ID: | HGNC:11831 | RefSeq IDs: | NM_001172643 |
Entrez Gene ID: | 7084 | Ensembl Gene ID: | ENSG00000166548 |
VEGA IDs: | OTTHUMG00000137499 | UniProt ID: | O00142 |
UCSC ID: | uc002eos.2 | OMIM ID: | 188250 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS10805.1 |
The TK2 gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants.
Function: Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.
Products for TK2 gene
Catalog | Product Name | Application | Company |
GFS:E01646 | thymidine kinase 2, mitochondrial; ELISA kit | ELISA | n/a |
GFS:A01646 | thymidine kinase 2, mitochondrial; Anti | ANTIBODIES | n/a |
GFS:P01646 | thymidine kinase 2, mitochondrial; Protien | Protien | n/a |