Symbol: Name: ID: |
BTK Bruton agammaglobulinemia tyrosine kinase GFS:1219 |
Gene name: | BTK |
Chromosome: | Xq21.33-q22 |
Previous Symbols: | AGMX1, IMD1 |
Previous Names: | |
Aliases: | ATK, XLA, PSCTK1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88216 | Rat Genome Database ID: | RGD:1359683 |
HGNC ID: | HGNC:1133 | RefSeq IDs: | NM_000061 |
Entrez Gene ID: | 695 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000022022 | UniProt ID: | Q06187 |
UCSC ID: | uc004ehg.2 | OMIM ID: | 300300 |
Pubmed: | PMID8380905 | ||
CCDS IDs: | CCDSCCDS14482.1 |
Bruton's tyrosine kinase (or Btk) is a type of kinase enzyme implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Its exact mechanism of action remains unknown, but it plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The BTK gene is located on the X chromosome.[1] At least 400 mutations of the BTK gene have been identified. Btk contains a PH domain which binds.The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.
Products for BTK gene
Catalog | Product Name | Application | Company |
GFS:E01219 | Bruton agammaglobulinemia tyrosine kinase; ELISA kit | ELISA | n/a |
GFS:A01219 | Bruton agammaglobulinemia tyrosine kinase; Anti | ANTIBODIES | n/a |
GFS:P01219 | Bruton agammaglobulinemia tyrosine kinase; Protien | Protien | n/a |