Symbol: Name: ID: |
RTKN rhotekin GFS:408 |
Gene name: | RTKN |
Chromosome: | 2p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | B5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107371 | Rat Genome Database ID: | RGD:727874 |
HGNC ID: | HGNC:10466 | RefSeq IDs: | NM_001015055 |
Entrez Gene ID: | 6242 | Ensembl Gene ID: | ENSG00000114993 |
VEGA IDs: | OTTHUMG00000129955 | UniProt ID: | Q9BST9 |
UCSC ID: | uc002sle.2 | OMIM ID: | 602288 |
Pubmed: | PMID9073523 PMID 10940294 | ||
CCDS IDs: | CCDSCCDS1941.1 CCDS CCDS33226.1 CCDS CCDS42699.1 |
RTKN encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Products for RTKN gene
Catalog | Product Name | Application | Company |
GFS:E00408 | rhotekin; ELISA kit | ELISA | n/a |
GFS:A00408 | rhotekin; Anti | ANTIBODIES | n/a |
GFS:P00408 | rhotekin; Protien | Protien | n/a |