Symbol: Name: ID: |
TXN thioredoxin GFS:2232 |
Gene name: | TXN |
Chromosome: | 9q31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TRX |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98874 | Rat Genome Database ID: | RGD:621157 |
HGNC ID: | HGNC:12435 | RefSeq IDs: | NM_003329 |
Entrez Gene ID: | 7295 | Ensembl Gene ID: | ENSG00000136810 |
VEGA IDs: | OTTHUMG00000020480 | UniProt ID: | P10599 |
UCSC ID: | uc004bep.1 | OMIM ID: | 187700 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS35103.1 |
Thioredoxin is a 12-kD oxidoreductase enzyme containing a dithiol-disulfide active site. It is ubiquitous and found in many organisms from plants and bacteria to mammals. Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, glucocorticoid receptor, and insulin. Reduction of insulin is classically used as an activity test.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Products for TXN gene
Catalog | Product Name | Application | Company |
GFS:E02232 | thioredoxin; ELISA kit | ELISA | n/a |
GFS:A02232 | thioredoxin; Anti | ANTIBODIES | n/a |
GFS:P02232 | thioredoxin; Protien | Protien | n/a |