Symbol: Name: ID: |
TXNRD1 thioredoxin reductase 1 GFS:2234 |
Gene name: | TXNRD1 |
Chromosome: | 12q23-q24.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TXNR, GRIM-12, Trxr1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354175 | Rat Genome Database ID: | RGD:61959 |
HGNC ID: | HGNC:12437 | RefSeq IDs: | NM_001093771 |
Entrez Gene ID: | 7296 | Ensembl Gene ID: | ENSG00000198431 |
VEGA IDs: | UniProt ID: | Q16881 | |
UCSC ID: | uc010swk.1 | OMIM ID: | 601112 |
Pubmed: | PMID7589432 | ||
CCDS IDs: |
Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene.
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq].
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Products for TXNRD1 gene
Catalog | Product Name | Application | Company |
GFS:E02234 | thioredoxin reductase 1; ELISA kit | ELISA | n/a |
GFS:A02234 | thioredoxin reductase 1; Anti | ANTIBODIES | n/a |
GFS:P02234 | thioredoxin reductase 1; Protien | Protien | n/a |