Symbol: Name: ID: |
TXNDC3 thioredoxin domain containing 3 (spermatozoa) GFS:5580 |
Gene name: | TXNDC3 |
Chromosome: | 7p15.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CILD6, NME8, SPTRX2 |
Name Aliases: | sperm-specific thioredoxin 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1920662 | Rat Genome Database ID: | RGD:735069 |
HGNC ID: | HGNC:16473 | RefSeq IDs: | NM_016616 |
Entrez Gene ID: | 51314 | Ensembl Gene ID: | ENSG00000086288 |
VEGA IDs: | OTTHUMG00000023716 | UniProt ID: | Q8N427 |
UCSC ID: | uc003tfn.2 | OMIM ID: | 607421 |
Pubmed: | PMID11737268 PMID 19852809 | ||
CCDS IDs: | CCDSCCDS5452.1 |
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009].
Function: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
Products for TXNDC3 gene
Catalog | Product Name | Application | Company |
GFS:E05580 | thioredoxin domain containing 3 (spermatozoa); ELISA kit | ELISA | n/a |
GFS:A05580 | thioredoxin domain containing 3 (spermatozoa); Anti | ANTIBODIES | n/a |
GFS:P05580 | thioredoxin domain containing 3 (spermatozoa); Protien | Protien | n/a |