Symbol: Name: ID: |
TXNIP thioredoxin interacting protein GFS:6042 |
Gene name: | TXNIP |
Chromosome: | 1q11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | VDUP1, EST01027, HHCPA78, THIF |
Name Aliases: | upregulated by 1,25-dihydroxyvitamin D-3, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889549 | Rat Genome Database ID: | RGD:620886 |
HGNC ID: | HGNC:16952 | RefSeq IDs: | NM_006472 |
Entrez Gene ID: | 10628 | Ensembl Gene ID: | ENSG00000117289 |
VEGA IDs: | OTTHUMG00000013755 | UniProt ID: | Q9H3M7 |
UCSC ID: | uc001enn.3 | OMIM ID: | 606599 |
Pubmed: | PMID8086474 | ||
CCDS IDs: | CCDSCCDS913.1 |
Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.
Function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
Products for TXNIP gene
Catalog | Product Name | Application | Company |
GFS:E06042 | thioredoxin interacting protein; ELISA kit | ELISA | n/a |
GFS:A06042 | thioredoxin interacting protein; Anti | ANTIBODIES | n/a |
GFS:P06042 | thioredoxin interacting protein; Protien | Protien | n/a |