Symbol: Name: ID: |
TXNRD2 thioredoxin reductase 2 GFS:7041 |
Gene name: | TXNRD2 |
Chromosome: | 22q11.21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TR, TRXR2, TR3 |
Name Aliases: | thioredoxin reductase beta, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1347023 | Rat Genome Database ID: | RGD:61960 |
HGNC ID: | HGNC:18155 | RefSeq IDs: | NM_006440 |
Entrez Gene ID: | 10587 | Ensembl Gene ID: | ENSG00000184470 |
VEGA IDs: | OTTHUMG00000149975 | UniProt ID: | Q9NNW7 |
UCSC ID: | uc011ahc.1 | OMIM ID: | 606448 |
Pubmed: | PMID9923614 PMID 10215850 PMID 11012661 | ||
CCDS IDs: | CCDSCCDS42981.1 |
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Products for TXNRD2 gene
Catalog | Product Name | Application | Company |
GFS:E07041 | thioredoxin reductase 2; ELISA kit | ELISA | n/a |
GFS:A07041 | thioredoxin reductase 2; Anti | ANTIBODIES | n/a |
GFS:P07041 | thioredoxin reductase 2; Protien | Protien | n/a |