Symbol: Name: ID: |
SCN11A sodium channel, voltage-gated, type XI, alpha subunit GFS:509 |
Gene name: | SCN11A |
Chromosome: | 3p22.2 |
Previous Symbols: | SCN12A |
Previous Names: | sodium channel, voltage-gated, type XI, alpha polypeptide, "sodium channel, voltage-gated, type XII, alpha" |
Aliases: | Nav1.9, NaN, SNS-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1345149 | Rat Genome Database ID: | RGD:3630 |
HGNC ID: | HGNC:10583 | RefSeq IDs: | NM_014139 |
Entrez Gene ID: | 11280 | Ensembl Gene ID: | ENSG00000168356 |
VEGA IDs: | OTTHUMG00000048246 | UniProt ID: | Q9UI33 |
UCSC ID: | uc011ays.1 | OMIM ID: | 604385 |
Pubmed: | PMID10444332 PMID 16382098 | ||
CCDS IDs: | CCDSCCDS33737.1 |
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM].
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization
Products for SCN11A gene
Catalog | Product Name | Application | Company |
GFS:E00509 | sodium channel, voltage-gated, type XI, alpha subunit; ELISA kit | ELISA | n/a |
GFS:A00509 | sodium channel, voltage-gated, type XI, alpha subunit; Anti | ANTIBODIES | n/a |
GFS:P00509 | sodium channel, voltage-gated, type XI, alpha subunit; Protien | Protien | n/a |