Symbol: Name: ID: |
SCN2A sodium channel, voltage-gated, type II, alpha subunit GFS:512 |
Gene name: | SCN2A |
Chromosome: | 2q24.3 |
Previous Symbols: | SCN2A1, SCN2A2 |
Previous Names: | sodium channel, voltage-gated, type II, alpha 2 polypeptide, "sodium channel, voltage-gated, type II, alpha 1 polypeptide" |
Aliases: | Nav1.2, HBSCII, HBSCI |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:10588 | RefSeq IDs: | NM_001040142 |
Entrez Gene ID: | 6326 | Ensembl Gene ID: | ENSG00000136531 |
VEGA IDs: | OTTHUMG00000044172 | UniProt ID: | Q99250 |
UCSC ID: | uc002ude.2 | OMIM ID: | 182390 |
Pubmed: | PMID1317301 PMID 16382098 | ||
CCDS IDs: | CCDSCCDS33313.1 CCDS CCDS33314.1 |
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient
Products for SCN2A gene
Catalog | Product Name | Application | Company |
GFS:E00512 | sodium channel, voltage-gated, type II, alpha subunit; ELISA kit | ELISA | n/a |
GFS:A00512 | sodium channel, voltage-gated, type II, alpha subunit; Anti | ANTIBODIES | n/a |
GFS:P00512 | sodium channel, voltage-gated, type II, alpha subunit; Protien | Protien | n/a |