Symbol: Name: ID: |
SCNN1D sodium channel, nonvoltage-gated 1, delta GFS:525 |
Gene name: | SCNN1D |
Chromosome: | 1p36.3-p36.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ENaCdelta, dNaCh |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:10601 | RefSeq IDs: | NM_001130413 |
Entrez Gene ID: | 6339 | Ensembl Gene ID: | ENSG00000162572 |
VEGA IDs: | OTTHUMG00000002081 | UniProt ID: | P51172 |
UCSC ID: | uc001adw.2 | OMIM ID: | 601328 |
Pubmed: | PMID8661065 | ||
CCDS IDs: | CCDSCCDS44037.1 |
Amiloride-sensitive sodium channel subunit delta is a protein that in humans is encoded by the SCNN1D gene.Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception
Epithelial sodium channels (ENaCs) are highly selective Na+ channels that are localized to polarized epithelial cells. They are responsible for sodium reabsorption in the distal kidney tubule, and have similar functions in the alveoli and colon. These channels transport Na+ across the epithelium using energy from the Na+, K+-ATPase, and constitute one of the essential mechanisms in regulation of sodium balance, blood volume and blood pressure. There are four ENaC subunits; alpha, beta, gamma and delta, which form functional heterotetramers. The kidney ENaC is thought to be a heterotetramer of 2alpha:1beta:1gamma. ENaCs are tonically open at rest. Ion flux is regulated by aldosterone-, vasopressin- and glucocorticoid-mediated changes in ENaC gene transcription and phosphatidylinositides act to stabilize the channel.
Products for SCNN1D gene
Catalog | Product Name | Application | Company |
GFS:E00525 | sodium channel, nonvoltage-gated 1, delta; ELISA kit | ELISA | n/a |
GFS:A00525 | sodium channel, nonvoltage-gated 1, delta; Anti | ANTIBODIES | n/a |
GFS:P00525 | sodium channel, nonvoltage-gated 1, delta; Protien | Protien | n/a |