Symbol: Name: ID: |
SIRT7 sirtuin 7 GFS:4220 |
Gene name: | SIRT7 |
Chromosome: | 17q25.3 |
Previous Symbols: | |
Previous Names: | sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7, "sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2385849 | Rat Genome Database ID: | |
HGNC ID: | HGNC:14935 | RefSeq IDs: | NM_016538 |
Entrez Gene ID: | 51547 | Ensembl Gene ID: | ENSG00000187531 |
VEGA IDs: | UniProt ID: | Q9NRC8 | |
UCSC ID: | uc002kcj.1 | OMIM ID: | 606212 |
Pubmed: | PMID10873683 PMID 16618798 | ||
CCDS IDs: | CCDSCCDS11792.1 |
NAD-dependent deacetylase sirtuin-7 is an enzyme that in humans is encoded by the SIRT7 gene.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008].
Function: NAD-dependent protein deacetylase. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex.
Products for SIRT7 gene
Catalog | Product Name | Application | Company |
GFS:E04220 | sirtuin 7; ELISA kit | ELISA | n/a |
GFS:A04220 | sirtuin 7; Anti | ANTIBODIES | n/a |
GFS:P04220 | sirtuin 7; Protien | Protien | n/a |