Symbol: Name: ID: |
SIRT2 sirtuin 2 GFS:794 |
Gene name: | SIRT2 |
Chromosome: | 19q13 |
Previous Symbols: | SIR2L |
Previous Names: | sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2, "sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927664 | Rat Genome Database ID: | RGD:621481 |
HGNC ID: | HGNC:10886 | RefSeq IDs: | NR_034146 |
Entrez Gene ID: | 22933 | Ensembl Gene ID: | ENSG00000068903 |
VEGA IDs: | OTTHUMG00000150480 | UniProt ID: | Q8IXJ6 |
UCSC ID: | uc002ojt.1 | OMIM ID: | 604480 |
Pubmed: | PMID10393250 PMID 10381378 | ||
CCDS IDs: | CCDSCCDS12523.1 CCDS CCDS46069.1 |
NAD-dependent deacetylase sirtuin-2 is an enzyme that in humans is encoded by the SIRT2 gene. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq].
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process through their role in resistance to cellular stress.
Products for SIRT2 gene
Catalog | Product Name | Application | Company |
GFS:E00794 | sirtuin 2; ELISA kit | ELISA | n/a |
GFS:A00794 | sirtuin 2; Anti | ANTIBODIES | n/a |
GFS:P00794 | sirtuin 2; Protien | Protien | n/a |