Symbol: Name: ID: |
SIRT6 sirtuin 6 GFS:4219 |
Gene name: | SIRT6 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6, "sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354161 | Rat Genome Database ID: | RGD:1305216 |
HGNC ID: | HGNC:14934 | RefSeq IDs: | NM_001193285 |
Entrez Gene ID: | 51548 | Ensembl Gene ID: | ENSG00000077463 |
VEGA IDs: | UniProt ID: | Q8N6T7 | |
UCSC ID: | uc002lzo.2 | OMIM ID: | 606211 |
Pubmed: | PMID10873683 | ||
CCDS IDs: | CCDSCCDS12122.1 |
Mono-ADP-ribosyltransferase sirtuin-6 is an enzyme that in humans is encoded by the SIRT6 gene.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010].
Function: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity).
Products for SIRT6 gene
Catalog | Product Name | Application | Company |
GFS:E04219 | sirtuin 6; ELISA kit | ELISA | n/a |
GFS:A04219 | sirtuin 6; Anti | ANTIBODIES | n/a |
GFS:P04219 | sirtuin 6; Protien | Protien | n/a |