Symbol: Name: ID: |
SIRT4 sirtuin 4 GFS:4217 |
Gene name: | SIRT4 |
Chromosome: | 12q24.31 |
Previous Symbols: | |
Previous Names: | sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4, "sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)" |
Aliases: | SIR2L4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1922637 | Rat Genome Database ID: | RGD:1310413 |
HGNC ID: | HGNC:14932 | RefSeq IDs: | NM_012240 |
Entrez Gene ID: | 23409 | Ensembl Gene ID: | ENSG00000089163 |
VEGA IDs: | UniProt ID: | Q9Y6E7 | |
UCSC ID: | uc001tyc.2 | OMIM ID: | 604482 |
Pubmed: | PMID10381378 | ||
CCDS IDs: | CCDSCCDS9194.1 |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008].
Function: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no detectable protein deacetylase activity.
Products for SIRT4 gene
Catalog | Product Name | Application | Company |
GFS:E04217 | sirtuin 4; ELISA kit | ELISA | n/a |
GFS:A04217 | sirtuin 4; Anti | ANTIBODIES | n/a |
GFS:P04217 | sirtuin 4; Protien | Protien | n/a |