Symbol: Name: ID: |
SIGLEC8 sialic acid binding Ig-like lectin 8 GFS:786 |
Gene name: | SIGLEC8 |
Chromosome: | 19q13.33-q13.41 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SIGLEC-8, SAF2, SIGLEC8L, MGC59785 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:10877 | RefSeq IDs: | NM_014442 |
Entrez Gene ID: | 27181 | Ensembl Gene ID: | ENSG00000105366 |
VEGA IDs: | OTTHUMG00000071725 | UniProt ID: | Q9NYZ4 |
UCSC ID: | uc002pwt.2 | OMIM ID: | 605639 |
Pubmed: | PMID10625619 | ||
CCDS IDs: | CCDSCCDS33086.1 |
Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the SIGLEC8 gene. Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Products for SIGLEC8 gene
Catalog | Product Name | Application | Company |
GFS:E00786 | sialic acid binding Ig-like lectin 8; ELISA kit | ELISA | n/a |
GFS:A00786 | sialic acid binding Ig-like lectin 8; Anti | ANTIBODIES | n/a |
GFS:P00786 | sialic acid binding Ig-like lectin 8; Protien | Protien | n/a |