Symbol: Name: ID: |
SIGLEC12 sialic acid binding Ig-like lectin 12 GFS:4690 |
Gene name: | SIGLEC12 |
Chromosome: | 19q13.41 |
Previous Symbols: | SIGLECL1 |
Previous Names: | SIGLEC-like 1 |
Aliases: | SLG, S2V, Siglec-XII, Siglec-12, Siglec-L1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:15482 | RefSeq IDs: | NM_033329 |
Entrez Gene ID: | 89858 | Ensembl Gene ID: | ENSG00000254521 |
VEGA IDs: | OTTHUMG00000071727 | UniProt ID: | Q96PQ1 |
UCSC ID: | uc002pwx.1 | OMIM ID: | 606094 |
Pubmed: | PMID11409877 PMID 11328818 | ||
CCDS IDs: | CCDSCCDS12833.1 |
Sialic acid-binding Ig-like lectin 12 is a protein that in humans is encoded by the SIGLEC12 gene.
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Products for SIGLEC12 gene
Catalog | Product Name | Application | Company |
GFS:E04690 | sialic acid binding Ig-like lectin 12; ELISA kit | ELISA | n/a |
GFS:A04690 | sialic acid binding Ig-like lectin 12; Anti | ANTIBODIES | n/a |
GFS:P04690 | sialic acid binding Ig-like lectin 12; Protien | Protien | n/a |