Symbol: Name: ID: |
SIGLEC5 sialic acid binding Ig-like lectin 5 GFS:783 |
Gene name: | SIGLEC5 |
Chromosome: | 19q13.3 |
Previous Symbols: | CD33L2 |
Previous Names: | |
Aliases: | OB-BP2, SIGLEC-5, CD170 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2681107 | Rat Genome Database ID: | RGD:1305432 |
HGNC ID: | HGNC:10874 | RefSeq IDs: | NM_003830 |
Entrez Gene ID: | 8778 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000071722 | UniProt ID: | O15389 |
UCSC ID: | uc002pxe.2 | OMIM ID: | 604200 |
Pubmed: | PMID10343116 | ||
CCDS IDs: | CCDSCCDS33088.1 |
Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. The sialic acid-binding immunoglobulin-like lectins (SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin (Ig) superfamily that mediate protein-carbohydrate interactions. They specifically interact with sialic acids in glycoproteins and glycolipids, with each SIGLEC having a particular preference for both the nature of the sialic acid and its glycosidic linkage to adjacent sugars. SIGLECs have similar structures, including extracellular Ig-like domains composed of an N-terminal V-set domain followed by varying numbers of C2-set domains. It appears that all SIGLECs have an unusual arrangement of conserved cysteine residues in the V-set and adjacent C2-set domains. Most SIGLECs are expressed uniquely within the hematopoietic system (Cornish et al., 1998 [PubMed 9731071]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Products for SIGLEC5 gene
Catalog | Product Name | Application | Company |
GFS:E00783 | sialic acid binding Ig-like lectin 5; ELISA kit | ELISA | n/a |
GFS:A00783 | sialic acid binding Ig-like lectin 5; Anti | ANTIBODIES | n/a |
GFS:P00783 | sialic acid binding Ig-like lectin 5; Protien | Protien | n/a |