Symbol: Name: ID: |
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin GFS:1034 |
Gene name: | SIGLEC1 |
Chromosome: | 20p13 |
Previous Symbols: | SN |
Previous Names: | sialoadhesin |
Aliases: | SIGLEC-1, CD169, FLJ00051, FLJ00055, FLJ00073, FLJ32150, dJ1009E24.1, sialoadhesin |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99668 | Rat Genome Database ID: | RGD:1311953 |
HGNC ID: | HGNC:11127 | RefSeq IDs: | NM_023068 |
Entrez Gene ID: | 6614 | Ensembl Gene ID: | ENSG00000088827 |
VEGA IDs: | OTTHUMG00000031757 | UniProt ID: | Q9BZZ2 |
UCSC ID: | uc002wja.2 | OMIM ID: | 600751 |
Pubmed: | PMID8530048 | ||
CCDS IDs: | CCDSCCDS13060.1 |
SIGLEC1 encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq].
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.
Products for SIGLEC1 gene
Catalog | Product Name | Application | Company |
GFS:E01034 | sialic acid binding Ig-like lectin 1, sialoadhesin; ELISA kit | ELISA | n/a |
GFS:A01034 | sialic acid binding Ig-like lectin 1, sialoadhesin; Anti | ANTIBODIES | n/a |
GFS:P01034 | sialic acid binding Ig-like lectin 1, sialoadhesin; Protien | Protien | n/a |