Symbol: Name: ID: |
SIGLEC7 sialic acid binding Ig-like lectin 7 GFS:785 |
Gene name: | SIGLEC7 |
Chromosome: | 19q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SIGLEC-7, p75/AIRM1, QA79, CD328 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1932475 | Rat Genome Database ID: | |
HGNC ID: | HGNC:10876 | RefSeq IDs: | NM_014385 |
Entrez Gene ID: | 27036 | Ensembl Gene ID: | ENSG00000168995 |
VEGA IDs: | UniProt ID: | Q9Y286 | |
UCSC ID: | uc002pvv.1 | OMIM ID: | 604410 |
Pubmed: | PMID10567377 | ||
CCDS IDs: | CCDSCCDS12826.1 CCDS CCDS42601.1 |
Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Products for SIGLEC7 gene
Catalog | Product Name | Application | Company |
GFS:E00785 | sialic acid binding Ig-like lectin 7; ELISA kit | ELISA | n/a |
GFS:A00785 | sialic acid binding Ig-like lectin 7; Anti | ANTIBODIES | n/a |
GFS:P00785 | sialic acid binding Ig-like lectin 7; Protien | Protien | n/a |