Symbol: Name: ID: |
SIGLEC11 sialic acid binding Ig-like lectin 11 GFS:4815 |
Gene name: | SIGLEC11 |
Chromosome: | 19q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:15622 | RefSeq IDs: | NM_001135163 |
Entrez Gene ID: | 114132 | Ensembl Gene ID: | ENSG00000161640 |
VEGA IDs: | OTTHUMG00000157077 | UniProt ID: | Q96RL6 |
UCSC ID: | uc010ybh.1 | OMIM ID: | 607157 |
Pubmed: | PMID11986327 | ||
CCDS IDs: | CCDSCCDS12790.2 CCDS CCDS46150.1 |
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Products for SIGLEC11 gene
Catalog | Product Name | Application | Company |
GFS:E04815 | sialic acid binding Ig-like lectin 11; ELISA kit | ELISA | n/a |
GFS:A04815 | sialic acid binding Ig-like lectin 11; Anti | ANTIBODIES | n/a |
GFS:P04815 | sialic acid binding Ig-like lectin 11; Protien | Protien | n/a |