Symbol: Name: ID: |
SIGLEC10 sialic acid binding Ig-like lectin 10 GFS:4813 |
Gene name: | SIGLEC10 |
Chromosome: | 19q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SIGLEC-10, SLG2, PRO940, MGC126774 |
Name Aliases: | sialic acid binding Ig-like lectin 10 Ig-like lectin 7, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2443630 | Rat Genome Database ID: | RGD:1307441 |
HGNC ID: | HGNC:15620 | RefSeq IDs: | NM_001171156 |
Entrez Gene ID: | 89790 | Ensembl Gene ID: | ENSG00000142512 |
VEGA IDs: | OTTHUMG00000071720 | UniProt ID: | Q96LC7 |
UCSC ID: | uc002pwo.2 | OMIM ID: | 606091 |
Pubmed: | PMID11284738 | ||
CCDS IDs: | CCDSCCDS12832.1 |
Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002].
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Products for SIGLEC10 gene
Catalog | Product Name | Application | Company |
GFS:E04813 | sialic acid binding Ig-like lectin 10; ELISA kit | ELISA | n/a |
GFS:A04813 | sialic acid binding Ig-like lectin 10; Anti | ANTIBODIES | n/a |
GFS:P04813 | sialic acid binding Ig-like lectin 10; Protien | Protien | n/a |