Symbol: Name: ID: |
RNF8 ring finger protein 8 GFS:68 |
Gene name: | RNF8 |
Chromosome: | 6p21.3 |
Previous Symbols: | |
Previous Names: | ring finger protein (C3HC4 type) 8 |
Aliases: | KIAA0646 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929069 | Rat Genome Database ID: | RGD:1308035 |
HGNC ID: | HGNC:10071 | RefSeq IDs: | NM_003958 |
Entrez Gene ID: | 9025 | Ensembl Gene ID: | ENSG00000112130 |
VEGA IDs: | OTTHUMG00000014620 | UniProt ID: | O76064 |
UCSC ID: | uc003onq.3 | OMIM ID: | 611685 |
Pubmed: | PMID9734811 PMID 9852682 | ||
CCDS IDs: | CCDSCCDS4833.1 CCDS CCDS4834.1 |
The protein encoded by ring finger protein 8 contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
E3 ubiquitin-protein ligase required for assembly of repair proteins to sites of DNA damage. Catalyzes the \'Lys-63\'-linked ubiquitination of histone H2A and H2AX. Following DNA double-strand breaks (DSBs), it is recruited to the sites of damage by ATM-phosphorylated MDC1, mediates the ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Promotes the formation of \'Lys-63\'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBE2N/UBC13. Substrates that are polyubiquitinated at \'Lys-63\' are usually not targeted for degradation. Enforces the G2/M DNA damage checkpoint. Controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites following DNA double-strand breaks (DSBs). Ubiquitination of histone H2A requires UBE2N but not MMS2 (UBE2V2). May also ubiquitinate histone H2B. Catalyzes the \'Lys-63\'-linked ubiquitination of PCNA. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2
Products for RNF8 gene
Catalog | Product Name | Application | Company |
GFS:E00068 | ring finger protein 8; ELISA kit | ELISA | n/a |
GFS:A00068 | ring finger protein 8; Anti | ANTIBODIES | n/a |
GFS:P00068 | ring finger protein 8; Protien | Protien | n/a |