Symbol: Name: ID: |
RNF7 ring finger protein 7 GFS:67 |
Gene name: | RNF7 |
Chromosome: | 3q22-q24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SAG, ROC2, CKBBP1 |
Name Aliases: | sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1337096 | Rat Genome Database ID: | RGD:1311048 |
HGNC ID: | HGNC:10070 | RefSeq IDs: | NM_001201370 |
Entrez Gene ID: | 9616 | Ensembl Gene ID: | ENSG00000114125 |
VEGA IDs: | OTTHUMG00000141305 | UniProt ID: | Q9UBF6 |
UCSC ID: | uc003eud.2 | OMIM ID: | 603863 |
Pubmed: | PMID10082581 PMID 10230407 | ||
CCDS IDs: | CCDSCCDS3118.1 CCDS CCDS43158.1 |
The protein encoded by ring finger protein 7 is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents
Products for RNF7 gene
Catalog | Product Name | Application | Company |
GFS:E00067 | ring finger protein 7; ELISA kit | ELISA | n/a |
GFS:A00067 | ring finger protein 7; Anti | ANTIBODIES | n/a |
GFS:P00067 | ring finger protein 7; Protien | Protien | n/a |