Symbol: Name: ID: |
RNF5 ring finger protein 5 GFS:64 |
Gene name: | RNF5 |
Chromosome: | 6p21.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NG2, G16, RING5, RMA1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1860076 | Rat Genome Database ID: | |
HGNC ID: | HGNC:10068 | RefSeq IDs: | NM_006913 |
Entrez Gene ID: | 6048 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | Q99942 | |
UCSC ID: | uc003oaj.3 | OMIM ID: | 602677 |
Pubmed: | PMID9533025 | ||
CCDS IDs: | CCDSCCDS4745.1 |
The protein encoded by ring finger protein 5 contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the \'Lys-63\'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the \'Lys-48\'-linked polyubiquitination of TMEM173 at \'Lys-150\' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses
Products for RNF5 gene
Catalog | Product Name | Application | Company |
GFS:E00064 | ring finger protein 5; ELISA kit | ELISA | n/a |
GFS:A00064 | ring finger protein 5; Anti | ANTIBODIES | n/a |
GFS:P00064 | ring finger protein 5; Protien | Protien | n/a |