Symbol: Name: ID: |
RNF11 ring finger protein 11 GFS:51 |
Gene name: | RNF11 |
Chromosome: | 1p32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CGI-123, Sid1669p, MGC51169 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1352759 | Rat Genome Database ID: | RGD:1591050 |
HGNC ID: | HGNC:10056 | RefSeq IDs: | NM_014372 |
Entrez Gene ID: | 26994 | Ensembl Gene ID: | ENSG00000123091 |
VEGA IDs: | OTTHUMG00000008190 | UniProt ID: | Q9Y3C5 |
UCSC ID: | uc001csi.3 | OMIM ID: | 612598 |
Pubmed: | PMID10673045 PMID 10810093 | ||
CCDS IDs: | CCDSCCDS556.1 |
The protein encoded by ring finger protein 11 contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates \'Lys-63\' polyubiquitin chains on RIPK1 and catalyzes the formation of \'Lys-48\'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-appa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome
Products for RNF11 gene
Catalog | Product Name | Application | Company |
GFS:E00051 | ring finger protein 11; ELISA kit | ELISA | n/a |
GFS:A00051 | ring finger protein 11; Anti | ANTIBODIES | n/a |
GFS:P00051 | ring finger protein 11; Protien | Protien | n/a |