Symbol: Name: ID: |
RNF19A ring finger protein 19A GFS:3019 |
Gene name: | RNF19A |
Chromosome: | 8q22 |
Previous Symbols: | RNF19 |
Previous Names: | ring finger protein 19 |
Aliases: | dorfin, DKFZp566B1346 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353623 | Rat Genome Database ID: | RGD:1307807 |
HGNC ID: | HGNC:13432 | RefSeq IDs: | NM_015435 |
Entrez Gene ID: | 25897 | Ensembl Gene ID: | ENSG00000034677 |
VEGA IDs: | UniProt ID: | Q9NV58 | |
UCSC ID: | uc003yjj.1 | OMIM ID: | 607119 |
Pubmed: | PMID11237715 PMID 10976766 | ||
CCDS IDs: | CCDSCCDS6286.1 |
E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.
The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq].
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
Products for RNF19A gene
Catalog | Product Name | Application | Company |
GFS:E03019 | ring finger protein 19A; ELISA kit | ELISA | n/a |
GFS:A03019 | ring finger protein 19A; Anti | ANTIBODIES | n/a |
GFS:P03019 | ring finger protein 19A; Protien | Protien | n/a |