Symbol: Name: ID: |
RNF41 ring finger protein 41 GFS:7258 |
Gene name: | RNF41 |
Chromosome: | 12q13.13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SBBI03 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914838 | Rat Genome Database ID: | RGD:1309557 |
HGNC ID: | HGNC:18401 | RefSeq IDs: | NM_005785 |
Entrez Gene ID: | 10193 | Ensembl Gene ID: | ENSG00000181852 |
VEGA IDs: | UniProt ID: | Q9H4P4 | |
UCSC ID: | uc001skf.1 | OMIM ID: | |
Pubmed: | |||
CCDS IDs: | CCDSCCDS8909.1 CCDS CCDS8910.1 |
E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011].
Function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, FLRF is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.
Products for RNF41 gene
Catalog | Product Name | Application | Company |
GFS:E07258 | ring finger protein 41; ELISA kit | ELISA | n/a |
GFS:A07258 | ring finger protein 41; Anti | ANTIBODIES | n/a |
GFS:P07258 | ring finger protein 41; Protien | Protien | n/a |