Symbol: Name: ID: |
RNF40 ring finger protein 40 GFS:5954 |
Gene name: | RNF40 |
Chromosome: | 16p11.2-p11.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0661, RBP95, BRE1B, STARING |
Name Aliases: | BRE1 E3 ubiquitin ligase homolog B (S. cerevisiae) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2142048 | Rat Genome Database ID: | RGD:628638 |
HGNC ID: | HGNC:16867 | RefSeq IDs: | NM_014771 |
Entrez Gene ID: | 9810 | Ensembl Gene ID: | ENSG00000103549 |
VEGA IDs: | OTTHUMG00000132394 | UniProt ID: | O75150 |
UCSC ID: | uc002dzq.2 | OMIM ID: | 607700 |
Pubmed: | PMID9734811 PMID 10944455 PMID 12121982 | ||
CCDS IDs: | CCDSCCDS10691.1 |
E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene.
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. Required for transcriptional activation of Hox genes.
Products for RNF40 gene
Catalog | Product Name | Application | Company |
GFS:E05954 | ring finger protein 40; ELISA kit | ELISA | n/a |
GFS:A05954 | ring finger protein 40; Anti | ANTIBODIES | n/a |
GFS:P05954 | ring finger protein 40; Protien | Protien | n/a |