Symbol: Name: ID: |
RNF34 ring finger protein 34 GFS:6381 |
Gene name: | RNF34 |
Chromosome: | 12q24.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RIFF, FLJ21786, RIF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2153340 | Rat Genome Database ID: | RGD:628636 |
HGNC ID: | HGNC:17297 | RefSeq IDs: | NM_025126 |
Entrez Gene ID: | 80196 | Ensembl Gene ID: | ENSG00000170633 |
VEGA IDs: | UniProt ID: | Q969K3 | |
UCSC ID: | uc001ual.1 | OMIM ID: | 608299 |
Pubmed: | PMID12118383 | ||
CCDS IDs: | CCDSCCDS9221.1 CCDS CCDS31915.1 |
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Function: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3-phosphate.
Products for RNF34 gene
Catalog | Product Name | Application | Company |
GFS:E06381 | ring finger protein 34; ELISA kit | ELISA | n/a |
GFS:A06381 | ring finger protein 34; Anti | ANTIBODIES | n/a |
GFS:P06381 | ring finger protein 34; Protien | Protien | n/a |