Symbol: Name: ID: |
RNF31 ring finger protein 31 GFS:5159 |
Gene name: | RNF31 |
Chromosome: | 14q11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ZIBRA, FLJ10111, FLJ23501 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934704 | Rat Genome Database ID: | RGD:1305513 |
HGNC ID: | HGNC:16031 | RefSeq IDs: | NM_017999 |
Entrez Gene ID: | 55072 | Ensembl Gene ID: | ENSG00000092098 |
VEGA IDs: | OTTHUMG00000028798 | UniProt ID: | Q96EP0 |
UCSC ID: | uc001wmn.1 | OMIM ID: | 612487 |
Pubmed: | PMID10422847 | ||
CCDS IDs: | CCDSCCDS41931.1 |
RING finger protein 31 is a protein that in humans is encoded by the RNF31 gene.
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. [provided by RefSeq, Jul 2008].
Function: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. LUBAC conjugates linear polyubiquitin to IKBKG at 'Lys-285' and 'Lys-309' and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.
Products for RNF31 gene
Catalog | Product Name | Application | Company |
GFS:E05159 | ring finger protein 31; ELISA kit | ELISA | n/a |
GFS:A05159 | ring finger protein 31; Anti | ANTIBODIES | n/a |
GFS:P05159 | ring finger protein 31; Protien | Protien | n/a |